Institution Name: Arkansas Children’s Hospital
Primary Author and Title: Bavana Ketha, MD
Co-Authors and Titles: Jeffrey Burford, MD; Melvin S. Dassinger, MD; Karen Kelley, RN; Donna Mathews, RN; Chelsey Boucher, RN; Michaela Kollisch, MD; Lori Gurien, MD; and Samuel Smith, MD
Name of Case Study: Practice Change to Decrease Opioid Prescription Doses in Outpatient Pediatric Surgery Patients
Opioid abuse and overdose in adults is a well-known public health crisis. It has been reported that more than 5 million people in the United States alone abuse opioids and more than 30,000 deaths annually are attributed directly to opioid overdose.
Only recently has the focus shifted to include the pediatric population. Often the first exposure can be directly attributed to receiving a prescription after surgery. Several studies have shown that opioid prescribing practices show variability between procedures, institutions, and surgeons and often result in excessive prescriptions.
Low-fidelity educational interventions often resulted in practice changes and can overall decrease the number of opioids prescribed.
Increased awareness of variability of opioid prescriptions at our own institution was brought about by participation in a study for the pediatric surgery research collaborative assessing opioid prescriptions after umbilical hernia repairs.
Participation in this study led us to add a question about opioid usage into our telephone prompt after our outpatient surgeries. We commonly use a surgical specialty nurse driven telephone follow-up in two weeks after outpatient surgeries to assess for general recovery, pain control, incision issues, or any need for clinic visits. Assessing the patients’ responses revealed that most patients after common outpatient surgeries were prescribed an excessive dose of opioids. The patients stated that on average they took 50 percent or less doses. In order to decrease excess pain medications available that could possibly contribute to addiction or abuse, we created a guideline for average doses to prescribe after common outpatient surgeries. We hypothesized that this change in protocol would decrease the number of opioids prescribed without an adverse effect on postoperative pain or complications in our patient population.
Prior to implementation of the prescription guideline, opioid prescriptions were at the discretion of the operating residents, fellows, or attending surgeons. We retrospectively reviewed all of our outpatient cases utilizing telephone follow-up for a total of six months from August 1, 2018, to January 31, 2019. Parents were asked specifically how many doses of opioids the patient used. The average doses used were then analyzed and information was relayed to the staff surgeons and fellows. All practitioners agreed to make an effort to decrease the opioid prescriptions since most doses were not being utilized. A guideline was created with all attending surgeons agreeing to adhere to the guideline (Table 1).
Surgery |
# of doses |
Laparoscopic cholecystectomy
|
6
|
Epigastric hernia
|
6
|
Laparoscopic appendectomy (non-perforated, discharged from PACU or from 24h obs)
|
4
|
Umbilical hernia
|
3
|
Gastrocutaneous fistula closure
|
3
|
Nuss bar removal
|
3
|
Inguinal hernia
|
2
|
Skin/soft tissue (lymph node biopsy, excision of skin lesions, removal of skin tag) Excludes: pilonidal
|
2
|
Port removal
|
2
|
Once the prescription guideline was created, the pediatric surgery team was educated by the research resident about its utilization. This guideline was distributed monthly from March 1, 2019, to August 31, 2019, to all rotating residents, the pediatric surgical fellows, as well the staff attendings. The guideline was also posted in the operating rooms as a reminder at discharge. Monthly reminders were sent to the new team members making them aware of the guideline with a copy attached to the email. We then conducted a retrospective review comparing opioid utilization pre and post guideline implementation. Statistical analysis was performed using Students’ t-test.
Six attending surgeons, two clinical surgery fellows, one research resident, rotating surgical and anesthesia residents, three nurse practitioners, and three surgical specialty nurses were involved in this project.
There was no additional cost to maintain this QI project.
There was no additional funding source for this intervention.
We retrospectively analyzed our institutional data pre and post guideline implementation. There was a total of 409 patients that underwent outpatient surgery during this study period. All patients were under the age of 18 and the nine most common surgeries were included in the analysis (Table 2). There were 203 patients in the pre-guideline group and 206 in the post guideline group. Average overall doses prescribed significantly decreased in the post guideline group (8.01 vs 4.63, p<0.001). There was also a significant decrease when compared in morphine milligram equivalents (MME) (39.42 vs 24.24, p<0.001). When evaluating individual operations, there was a significant reduction in the number of prescribed doses in seven out of nine and in MMEs in five out of nine. Although not included in the chart, the doses utilized by the patients were not significantly different between the pre and post protocol group. At the postoperative telephone follow-up, there were no further ER visits, clinic visits, or phone calls for pain control issues in either group.
Surgery
|
Dose (pre)
|
Dose (post)
|
p-value
|
MME (pre)
|
MME (post)
|
p-value
|
Laparoscopic Appendectomy, mean (n) |
9.23 (70) |
5.96 (73) |
<0.001 |
50.62 (70) |
36.84 (73) |
0.04 |
Umbilical hernia, mean (n)
|
6.81 (40)
|
3.52 (46)
|
<0.001
|
20.34 (40)
|
9.46 (46)
|
<0.001
|
Inguinal hernia, mean (n)
|
6.71 (21)
|
3.10 (20)
|
<0.001
|
23.15 (21)
|
7.38 (20)
|
0.004
|
Skin/soft tissue, mean (n)
|
7.21 (21)
|
4.17 (16)
|
0.02
|
36.29 (21)
|
21.93 (16)
|
0.19
|
Port removal, mean (n)
|
6.69 (13)
|
3.12 (18)
|
0.001
|
34.27 (13)
|
18.74 (18)
|
0.002
|
Laparoscopic Cholecystectomy, mean (n)
|
8.97 (17)
|
6.71 (14)
|
0.05
|
66.18 (17)
|
46.61 (14)
|
0.03
|
Gastrocutaneous fistula closure, mean (n)
|
7.05 (10)
|
3.86 (8)
|
0.01
|
21.59 (10)
|
14.45 (8)
|
0.42
|
Epigastric hernia, mean (n)
|
9.5 (8)
|
4 (8)
|
0.09
|
48.19 (8)
|
15.29 (8)
|
0.24
|
Nuss bar removal, mean (n)
|
10 (3)
|
6.33 (3)
|
0.01
|
75 (3)
|
47.5 (3)
|
0.09
|
MME = Morphine Milligram Equivalent