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Case Study

Practice Change to Decrease Opioid Prescription Doses in Outpatient Pediatric Surgery Patients

Arkansas Children's Hospital

General Information

Institution Name: Arkansas Children’s Hospital

Primary Author and Title: Bavana Ketha, MD

Co-Authors and Titles: Jeffrey Burford, MD; Melvin S. Dassinger, MD; Karen Kelley, RN; Donna Mathews, RN; Chelsey Boucher, RN; Michaela Kollisch, MD; Lori Gurien, MD; and Samuel Smith, MD

Name of Case Study: Practice Change to Decrease Opioid Prescription Doses in Outpatient Pediatric Surgery Patients

What Was Done?

Global Problem Addressed

Opioid abuse and overdose in adults is a well-known public health crisis. It has been reported that more than 5 million people in the United States alone abuse opioids and more than 30,000 deaths annually are attributed directly to opioid overdose.

Only recently has the focus shifted to include the pediatric population. Often the first exposure can be directly attributed to receiving a prescription after surgery. Several studies have shown that opioid prescribing practices show variability between procedures, institutions, and surgeons and often result in excessive prescriptions.

Low-fidelity educational interventions often resulted in practice changes and can overall decrease the number of opioids prescribed.

Identification of Local Problem

Increased awareness of variability of opioid prescriptions at our own institution was brought about by participation in a study for the pediatric surgery research collaborative assessing opioid prescriptions after umbilical hernia repairs.

Participation in this study led us to add a question about opioid usage into our telephone prompt after our outpatient surgeries. We commonly use a surgical specialty nurse driven telephone follow-up in two weeks after outpatient surgeries to assess for general recovery, pain control, incision issues, or any need for clinic visits. Assessing the patients’ responses revealed that most patients after common outpatient surgeries were prescribed an excessive dose of opioids. The patients stated that on average they took 50 percent or less doses. In order to decrease excess pain medications available that could possibly contribute to addiction or abuse, we created a guideline for average doses to prescribe after common outpatient surgeries. We hypothesized that this change in protocol would decrease the number of opioids prescribed without an adverse effect on postoperative pain or complications in our patient population.

How Was the Quality Improvement (QI) Activity Put in Place?

Context of the QI Activity

  • Arkansas Children’s Hospital is a 336-bed, free-standing academic and teaching children’s hospital.
  • The surgical team consists of six general surgeons, two surgical fellows, three nurse practitioners, a research resident, and several rotating surgical and anesthesia residents.
  • The quality improvement project was largely physician and fellow driven to standardize and improve opioid prescription patterns after outpatient surgeries.

Planning and Development Process

Prior to implementation of the prescription guideline, opioid prescriptions were at the discretion of the operating residents, fellows, or attending surgeons. We retrospectively reviewed all of our outpatient cases utilizing telephone follow-up for a total of six months from August 1, 2018, to January 31, 2019. Parents were asked specifically how many doses of opioids the patient used. The average doses used were then analyzed and information was relayed to the staff surgeons and fellows. All practitioners agreed to make an effort to decrease the opioid prescriptions since most doses were not being utilized. A guideline was created with all attending surgeons agreeing to adhere to the guideline (Table 1).

Table 1. Guideline of Prescription Doses

Surgery 

# of doses 

Laparoscopic cholecystectomy 
Epigastric hernia 
Laparoscopic appendectomy (non-perforated, discharged from PACU or from 24h obs) 
Umbilical hernia 
Gastrocutaneous fistula closure 
Nuss bar removal 
Inguinal hernia 
Skin/soft tissue (lymph node biopsy, excision of skin lesions, removal of skin tag) Excludes: pilonidal 
Port removal 

Description of the Quality Improvement Activity

Once the prescription guideline was created, the pediatric surgery team was educated by the research resident about its utilization. This guideline was distributed monthly from March 1, 2019, to August 31, 2019, to all rotating residents, the pediatric surgical fellows, as well the staff attendings. The guideline was also posted in the operating rooms as a reminder at discharge. Monthly reminders were sent to the new team members making them aware of the guideline with a copy attached to the email. We then conducted a retrospective review comparing opioid utilization pre and post guideline implementation. Statistical analysis was performed using Students’ t-test.

Resources Used and Skills Needed

Staff

Six attending surgeons, two clinical surgery fellows, one research resident, rotating surgical and anesthesia residents, three nurse practitioners, and three surgical specialty nurses were involved in this project.

Costs

There was no additional cost to maintain this QI project.

Budget

There was no additional funding source for this intervention.

What Were the Results?

Overall Results

We retrospectively analyzed our institutional data pre and post guideline implementation. There was a total of 409 patients that underwent outpatient surgery during this study period. All patients were under the age of 18 and the nine most common surgeries were included in the analysis (Table 2). There were 203 patients in the pre-guideline group and 206 in the post guideline group. Average overall doses prescribed significantly decreased in the post guideline group (8.01 vs 4.63, p<0.001). There was also a significant decrease when compared in morphine milligram equivalents (MME) (39.42 vs 24.24, p<0.001). When evaluating individual operations, there was a significant reduction in the number of prescribed doses in seven out of nine and in MMEs in five out of nine. Although not included in the chart, the doses utilized by the patients were not significantly different between the pre and post protocol group. At the postoperative telephone follow-up, there were no further ER visits, clinic visits, or phone calls for pain control issues in either group.

Setbacks

  • Initially with the change in the prompt to address opioid usage during telephone follow-up, there were several times that the question was not asked due to lack of practitioner education.
  • Parents could not always recall exact doses of opioids used.
  • Fellows and residents would sometimes prescribe different doses due to various reasons.
  • Fellow responses addressing non-compliance focused on disbelief that small volumes of medication, e.g., <5 ml, would adequately control pain or be filled by a non-pediatric pharmacy. Resident responses indicated lack of knowledge of the guidelines or forgetting to use them. Default prescription dosing in the electronic medical record that exceeded our guidelines was also identified as a reason for non-compliance.
Table 2. Outpatient Surgery Opioid Prescriptions
Surgery 
Dose (pre) 
Dose (post) 
p-value 
MME (pre) 
MME (post) 
p-value 

Laparoscopic Appendectomy, mean (n) 

9.23 (70) 

5.96 (73) 

<0.001 

50.62 (70) 

36.84 (73) 

0.04 

Umbilical hernia, mean (n) 
6.81 (40) 
3.52 (46) 
<0.001 
20.34 (40) 
9.46 (46) 
<0.001 
Inguinal hernia, mean (n) 
6.71 (21) 
3.10 (20) 
<0.001 
23.15 (21) 
7.38 (20) 
0.004 
Skin/soft tissue, mean (n) 
7.21 (21) 
4.17 (16) 
0.02 
36.29 (21) 
21.93 (16) 
0.19 
Port removal, mean (n) 
6.69 (13) 
3.12 (18) 
0.001 
34.27 (13) 
18.74 (18) 
0.002 
Laparoscopic Cholecystectomy, mean (n) 
8.97 (17) 
6.71 (14) 
0.05 
66.18 (17) 
46.61 (14) 
0.03 
Gastrocutaneous fistula closure, mean (n) 
7.05 (10) 
3.86 (8) 
0.01 
21.59 (10) 
14.45 (8) 
0.42 
Epigastric hernia, mean (n) 
9.5 (8) 
4 (8) 
0.09 
48.19 (8) 
15.29 (8) 
0.24 
Nuss bar removal, mean (n) 
10 (3) 
6.33 (3) 
0.01 
75 (3) 
47.5 (3) 
0.09 

MME = Morphine Milligram Equivalent 

Tips for Others

  • When trying to implement an opioid reduction quality improvement project, it is important to collect data to recognize institutional trends and practitioner variability of prescriptions.
  • All surgeons, residents, and practitioners need to commit to following the guideline and prescribe the mandated number of doses.
  • There should be a reliable follow-up method in place to check on the patient’s pain and to assess the number of opioid doses taken.
  • At the beginning and throughout implementation, there should be reminders to team members about the guideline as well as providing everyone with a copy of the guideline.
  • It is important to recognize that there will be some variability with prescriptions, sometimes based on physician preference, some pharmacy requirements, and sometimes based on the patient’s history.

References

  1. Bawa M, Mahajan JK, Aggerwal N, Sundaram J, Rao KL. Barriers to Pediatric Pain Management in Children Undergoing Surgery: A Survey of Health Care Providers. J Pain Palliat Care Pharmacother. 2015;29(4):353-358.
  2. Cairo SB, Calabro KA, Bowdish E, Reilly C, Watt S, Rothstein DH. Variation in postoperative narcotic prescribing after pediatric appendectomy. J Pediatr Surg. 2019;54(9):1866-1871. doi:10.1016/j.jpedsurg.2018.11.015.
  3. Garren BR, Lawrence MB, McNaull PP, et al. Opioid-prescribing patterns, storage, handling, and disposal in postoperative pediatric urology patients. J Pediatr Urol. 2019;15(3):260.e1-260.e7. doi:10.1016/j. jpurol.2019.02.009doi:10.3109/15360288.2015.1082010.
  4. Gee KM, Jones RE, Nevarez N, McClain LE, Wools G, Beres AL. No pain is gain: A prospective evaluation of strict non-opioid pain control after pediatric appendectomy. J Pediatr Surg. 2020;55(6):1043-1047. doi:10.1016/j. jpedsurg.2020.02.051.
  5. Messerer B, Gutmann A, Weinberg A, Sandner-Kiesling A. Implementation of a standardized pain management in a pediatric surgery unit. Pediatr Surg Int. 2010;26(9):879-889. doi:10.1007/s00383-010-2642-1.
  6. Thiels CA, Anderson SS, Ubl DS, et al. Wide Variation and Overprescription of Opioids After Elective Surgery. Ann Surg. 2017;266(4):564-573. doi:10.1097/SLA.0000000000002365.