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Case Study

Implementation of a Clinical Practice Guideline for Postoperative Management of Pediatric Appendicitis

University of California Davis

General Information

Institution Name: University of California Davis

Submitter Name: Melissa Vanover, MD

Name of Case Study: Implementation of a Clinical Practice Guideline for Postoperative Management of Pediatric Appendicitis

What Was Done?

Global Problem Addressed

Appendicitis is the most common cause of urgent abdominal surgery among children. In the U.S., approximately 53,000 children undergo appendectomy each year for acute appendicitis.1, 2 Despite a substantial amount of research and vigorous debate, there is no consensus regarding the optimal postoperative management of these children. Therefore, wide variation exists amongst pediatric surgeons and presents an opportunity for quality improvement endeavors.3,4

Identification of Local Problem

Appendectomy is a targeted procedure for the ACS NSQIP Pediatric Project, so institution-specific and national statistics are readily available. Following the first year of participation, it was recognized that UC Davis was amongst the highest quartile for length of stay (LOS) despite a lower postoperative complication rate than other institutions. Our patients had an average length of stay of 3.6 days compared with 2.6 days nationally. This was more pronounced for patients with complicated appendicitis who had an average length of stay of 6.5 days compared with 4.7 days nationally. Since postoperative complications could not account for the prolonged average length of hospitalizations, the most likely contributors were variability in postoperative management and inconsistent criteria for discharge.

How Was the Quality Improvement (QI) Activity Put in Place?

Context of the QI Activity

The UC Davis Medical Center is a tertiary referral center with a large catchment area that includes parts of Northern California, Southern Oregon, Nevada, and Idaho. It also serves as the primary teaching hospital for the UC Davis Medical School, with a wide range of residencies and fellowship programs. The adjoining UC Davis Children's Hospital offers comprehensive pediatric care, is the region's only Level 1 pediatric trauma center, and is the only Level 1 children's surgery center on the west coast, as verified by the American College of Surgeons. Over the year prior to the implementation of this initiative, 128 children underwent appendectomy for acute appendicitis, of which 58 (42%) were found to have complicated appendicitis.

The UC Davis Office of Graduate Medical Education encourages quality improvement endeavors, particularly multidisciplinary and interdepartmental projects, and offers grant funding through a competitive application process. Grant recipients are provided both financial and technical support to assist implementation. Intermittent updates are required to ensure progress is being made.

Planning and Development Process

Clinical practice guidelines have been described at other institutions and their use, in general, has been endorsed by the American Pediatric Surgical Association.5 Guidelines used at several other institutions were obtained and a literature review performed to guide development of a unique, local clinical practice guideline. The directors of Pediatric Antimicrobial Stewardship provided recommendations for postoperative antibiotic regimen, taking into consideration the local antibiogram. A first draft of the local clinical practice guideline was presented along with local performance metrics to the pediatric surgery department during a weekly departmental meeting. Individual meetings were then held with each pediatric surgeon to elicit detailed concerns and discuss potential alternatives to specific elements. The guideline was revised based on the accumulated feedback and subsequently received unanimous approval. The final approved guideline defined complicated appendicitis by specific intraoperative findings, established clear discharge criteria, and specified the postoperative antibiotic regimen.

Description of the Quality Improvement Activity

Once the clinical practice guideline was approved, it was disseminated by e-mail to all members of the pediatric surgery team, including surgeons, residents, nurse practitioners, and pharmacists. Laminated badge buddy cards were also distributed, and the guideline was posted in each of the resident work rooms and call rooms. An e-mail explaining the project and its background, along with the current iteration of the guideline, was sent to rotating residents a few days prior to the start of each rotation. Surgeons, rotating residents, and nurse practitioners were primarily responsible for ensuring that the guideline was followed.

The first iteration of the guideline was implemented on November 1, 2016, and it was periodically updated following the Plan-Do-Study-Act model.6 Data for all pediatric patients undergoing appendectomy were collected retrospectively from the electronic medical record. Data points of interest included:

  • Patient demographics
  • Transfer status
  • Diagnostic modality
  • Length of stay
  • Procedure performed (open vs laparoscopic)
  • Operating surgeon
  • lntraoperative findings (simple versus complicated appendicitis)
  • Pathology resuIts
  • lntraoperative culture results (if applicable)
  • Peripherally inserted central catheter (PICC) placement
  • Total parenteral nutrition (TPN) use
  • CBC results prior to discharge (if applicable)
  • Antibiotics prescribed at discharge
  • Duration of antibiotics (IV, PO, and total)
  • Compliance with the guideline
  • Infectious complications
  • Emergency room visits
  • Readmissions
  • 30-day follow-up

Children who underwent interval and incidental appendectomies were excluded from further analysis.

Analysis was performed by the lead research fellow after every three months of patient data to assess key outcomes, specifically length of stay and complication rates. Results were presented at the weekly pediatric surgery department meeting and potential changes proposed. Changes were approved by consensus and a new iteration of the guideline released every four months, allowing a month between study periods to assess outcomes and discuss changes.

implementation-of-clinical-practice-case-study-figure-2.png

Resources Used and Skills Needed

Staff

The pediatric surgery department is composed of nine pediatric surgeons, including a mix of academic and private practitioners, three to four rotating general surgery residents, and one to two dedicated nurse practitioners. The pediatric infectious disease department was also involved during development. One general surgery research fellow oversaw the development, implementation, data collection, and periodic analysis of the project.

Costs

Costs were minimal, limited to printing and laminating for distribution each new iteration of the guideline.

Funding

Funding was provided through a grant from the UC Davis Office of Graduate Medical Education.

What Were the Results?

Over the 12 months following implementation, decreases were seen in the length of stay for all children undergoing appendectomy for acute appendicitis from an average of 3.6 days to 2.6 days. For children with complicated appendicitis, the average length of stay decreased from 6.5 days to 5.4 days. Compliance with the guideline was high, observed in more than 93 percent of patients despite introduction of a new iteration every four months.

Table 1. Compliance with the clinical practice guideline after implementation.

Iteration 1

Iteration 2

Iteration 3

Overall

Compliance

97.6%

92.7%

94.6%

93.9%

Setbacks

No major setbacks were encountered, which is likely due to buy-in from each pediatric surgeon during development of the guideline.

Cost Savings

As mentioned, there was minimal direct cost related to implementation of this project. Cost data for the index hospitalization was obtained and the median direct and total per patient costs were calculated. Direct costs per patient decreased from $6,159 to $5,917, while total costs per patient decreased from $10,109 to $9,748. When these average per-patient savings were extrapolated out to the total number of patients treated for the year following implementation, there were estimated savings of $47,432 in direct costs and $70,756 in total costs. These estimates represent net savings, given the minimal monetary investment required.  

Tips for Others

It was important to identify a dedicated project lead to ensure timely guideline distribution and periodic analysis, as well as a surgeon champion to provide project support. Presentation of performance metrics, particularly areas of poor performance and national statistics, also increased motivation. Inclusion of all involved parties during guideline development was likely a crucial component for post-implementation compliance, as practice patterns prior to implementation were highly variable.

High rate of compliance was maintained through frequent, monthly reminders for new rotating residents, as well as updates to the surgeons every three months regarding outcomes and potential changes.

Distributed copies of the guideline should be numbered or dated to ensure easy identification of the newest iteration when changes are made. Alternatively, older versions could be collected and destroyed with each new release.

References

  1. HCUPnet, Healthcare Cost and Utilization Project. Agency for Healthcare Research and Quality, Rockville, MD. Available at: https://hcupnet.ahrq.gov/. Accessed June 27, 2018. 
  2. Dunn JCY. Appendicitis A2. In: Coran, Arnold G. Pediatric Surgery. 7th ed. Philadelphia, PA: Mosby; 20121255-1263. 
  3. Gross TS. et al. The contribution of practice variation to length of stay for children with perforated appendicitis. J Pediatr Surg. 2016;51(8):1292-1297. 
  4. Rice-Townsend S, et al. Variation in practice and resource utilization associated with the diagnosis and management of appendicitis at freestanding children's hospitals: implications for value-based comparative analysis. Ann Surg. 2014;259(6) 1228-1234. 
  5. Lee SL, et al. Antibiotics and appendicitis in the pediatric population: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review. J Pediatr Surg. 2010;45(11):2181-2185. 
  6. The Breakthrough Series: IHi's Collaborative Model for Achieving Breakthrough Improvement, in IHI Innovation Series white paper. Boston: Institute for Healthcare Improvement; 2003