Pancreatic Surgery

This collection of pancreatic surgery articles highlights advances in risk stratification, oncologic strategy, and multidisciplinary care. Studies explore improved characterization of pancreatic cysts through sequencing and natural history analyses, as well as evolving approaches to cancer detection, neoadjuvant therapy, and operative decision-making.

Additional contributions examine surgical outcomes, technical innovation, and disparities in care, alongside emerging therapies such as immunologic and ablative strategies. Together, these works reflect a continued shift toward more precise, patient-centered management in pancreatic surgery.

Scroll to the CME Articles section for opportunities to earn AMA PRA Category 1 Credits™ related to this collection.

Incidental Diagnosis of Pancreatic Cancer and Association with Improved Patient Outcomes: Assessing the Potential Clinical Use of Liquid Biopsy-Based Screening Tests

The association between incidental diagnosis and outcomes was investigated and role of liquid biopsies for detection was assessed. Incidental diagnosis (~10% of patients) was independently associated with improved survival and liquid biopsy performed equally well in asymptomatic and symptomatic patients suggesting their clinical role.

Baseline Characteristics and Use of Pretherapeutic 18F-Fluorodeoxyglucose-PET for Pancreatic Cancer

Most treatment-naive pancreatic ductal adenocarcinoma is FDG-avid and can be used to monitor metabolic responses over time during neoadjuvant chemotherapy as an adjunct response modality combined with traditional cross-sectional imaging and tumor marker responses. FDG-PET can detect extrapancreatic disease in a significant proportion of patients.

Yield of Staging Laparoscopy for Pancreatic Cancer in the Modern Era: Analysis of More than 1,000 Consecutive Patients

In this contemporary analysis, the yield of positive staging laparoscopy (gross metastases or positive peritoneal cytology) in patients with pancreatic cancer remained high. Preoperative risk factors for positive laparoscopy included indeterminate extrapancreatic lesions on imaging, younger age, large body/tail tumors, and elevated serum CA 19-9.

Articles

Characterizing Biological Behavior Beyond Morphologic Features: Next-Generation Sequencing Analysis of Large vs Small Pancreatic Cystic Lesions in a Large Multicenter Cohort of Patients

Kannan, Amudhan; Murimwa, Gilbert Z; Mansour, John C; et al

Evolution of the Indications and Outcomes of Total Pancreatectomy

Gudmundsdottir, Hallbera; Adjei Antwi, Stella K; Thiels, Cornelius A; et al

Disparity in Access to High-Volume Facilities for Pancreatic Surgery: Intersection of Race, Socioeconomics, and Geography

Brown, Noah S; Horns, Joshua J; Scaife, Courtney L

Operation Alone for Resectable Pancreatic Adenocarcinoma: Should We Operate if Multimodal Treatment Is Off the Table?

Anteby, Roi; Fagenholz, Peter J; Fernandez-del Castillo, Carlos; et al

Data Extraction and Curation from Radiology Reports for Pancreatic Cyst Surveillance Using Large Language Models

Choubey, Ankur P; Eguia, Emanuel; Hollingsworth, Alexander; et al

Assessing the Potential Difficulty of Left Pancreatectomy: International Modified Delphi Consensus

Ramia, Jose M; Villodre, Celia; Serradilla-Martín, Mario; et al

Sex Disparity and Procedure-Related Differences in Achieving an Ideal Outcome after Pancreatic Surgery: A National Observational Cohort Study

Roalsø, Marcus TT; Nymo, Linn Såve; Kleive, Dyre; et al

Natural History of Pancreatic Cyst with Diameter as Solitary Risk Factor

Choubey, Ankur P; Alessandris, Remo; Armstrong, Misha T; et al

Irreversible Electroporation and Beta-Glucan-Induced Trained Innate Immunity for Treatment of Pancreatic Ductal Adenocarcinoma: A Phase II Study

Martin, Robert CG II; Li, Yan; Shore, Emily A; et al

Multi-Institutional Analysis of Pancreaticoduodenectomy for Nonfamilial Periampullary Adenoma: A Novel Risk Score to Guide Shared Decision-Making

Mavani, Parit T; Sok, Caitlin; Eng, Nina; et al

Long-Term Islet Graft Functional Assessment in More than 500 Patients Undergoing Total Pancreatectomy with Intraportal Islet Autotransplantation

Bellin, Melena D; Eaton, Anne; Ramanathan, Karthik; et al

Textbook Neoadjuvant Experience: Defining a Novel Composite Outcomes Measure for Patients with Pancreatic Cancer Undergoing Neoadjuvant Therapy

Underwood, Patrick W; Leuschner, Thomas; Ejaz, Aslam; et al

Surgical Second Opinion for Pancreatic Cancer Patients

Quinn, Patrick L; Nikahd, Melica; Saiyed, Shah; et al

Two-Port Minimally Invasive Nephrolaparoscopic Retroperitoneal Debridement for Pancreatic Necrosis

Harrison, Jon M; Li, Amy Y; Sceats, Lindsay A; et al

Clinical Implications and Risk Factors of Dilatation of Remnant Pancreatic Duct at 1 Year after Pancreatoduodenectomy: A Prospective, Japanese, Multicenter, Observational Cohort Study (DAIMONJI Study)

Narita, Masato; Hatano, Etsuro; Kitamura, Koji; et al

Benchmark Outcomes for Distal Pancreatectomy: A Multicenter Prospective Snapshot Study from the Spanish Distal Pancreatectomy Project (SPANDISPAN)

Ramia, José M; Alcázar-López, Cándido F; Villodre-Tudela, Celia; et al

Recent Changes in the Management of High-Grade Blunt Pancreatic Injury in Children: A Nationwide Trend Analysis

Katsura, Morihiro; Ikenoue, Tatsuyoshi; Aoki, Makoto; et al

Using Oncolytic Virus to Retask CD19-Chimeric Antigen Receptor T Cells for Treatment of Pancreatic Cancer: Toward a Universal Chimeric Antigen Receptor T-Cell Strategy for Solid Tumor

Chen, Courtney; Park, Anthony K; Monroy, Isabel; et al

Postoperative Global Period Cost Reduction Using 3 Successive Risk-Stratified Pancreatectomy Clinical Pathways

Azimuddin, Ahad; Tzeng, Ching-Wei D; Prakash, Laura R; et al

Impact of Neoadjuvant Therapy for Pancreatic Cancer: Transatlantic Trend and Postoperative Outcomes Analysis

Davis, Catherine H; Augustinus, Simone; de Graaf, Nine; et al

CME Articles

April 2026

Impact of medicaid expansion on pancreatic adenocarcinoma survival in the southern US.
Biology vs barriers: the impact of socioeconomic disadvantage on overall survival in pancreatic cancer despite guideline-concordant treatment.

March 2026

Characterizing biological behavior beyond morphologic features: next generation sequencing analysis of large vs small pancreatic cystic lesions in a large multicenter cohort of patients.

November 2025

Operation alone for resectable pancreatic adenocarcinoma: should we operate if multimodal treatment is off the table?

October 2025

Sex disparity and procedure-related differences in achieving an ideal outcome after pancreatic surgery: a national observational cohort study.

July 2024

Baseline characteristics and utility of pretherapeutic fluorodeoxyglucose- positron emission tomography for pancreatic cancer for pancreatic cancer.

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Featured Video

Dr Kannan discusses his recently published article in JACS, Characterizing Biological Behavior Beyond Morphologic Features: Next Generation Sequencing Analysis of Large vs Small Pancreatic Cystic Lesions in a Large Multicenter Cohort of Patients.