Colorectal Cancer

FDA-approved colorectal cancer immunotherapy trials underrepresented non-Hispanic Black and Hispanic patients, limiting generalizability. Asian patients were adequately or overrepresented; gender representation was balanced. Findings highlight the need for more equitable and inclusive clinical trial recruitment.

Colorectal cancer (CRC) diagnosed as the first of multiple primary malignancies is associated with better overall and cancer-specific survival compared to isolated CRC or CRC as a second primary cancer. This group had less advanced disease and higher surgical treatment rates, highlighting the importance of cancer sequence in prognosis.

This multi-institutional retrospective study compared liver resection (LR) and microwave ablation (MWA) for solitary colorectal liver metastases (CRLM) <3 cm and found no significant difference in overall or disease-free survival. The findings support MWA as a non-inferior alternative to LR in selected patients.

Cancer incidence and mortality rates are decreasing in Appalachia but remain substantially higher and show slower improvements than among non-Appalachian populations. Within Appalachia, significantly worse rates are found in the Central subregion. Targeted research is needed to delineate and address factors driving Appalachian cancer disparities.

Retrospective analysis comparing cytoreduction and cytoreduction with HIPEC for peritoneal metastases from colorectal cancer demonstrating a benefit for HIPEC only in patients with a peritoneal cancer index score of 11 or greater.

Appalachian Kentucky patients with colon cancer have unique gene expression and tumor microbiome profiles which may impact outcomes.

In this study of 1339 children with carcinoid tumor of the appendix, there was no difference in survival between patients who underwent appendectomy or right hemicolectomy based on tumor characteristics including margin status. Utilization of right hemicolectomy should be further decreased

In an analysis of colorectal cancer (CRC) patients in a multi-institutional health system, higher social vulnerability index (SVI) at the census tract level was associated with greater complications, and decreased overall and CRC survival. SVI may constitute an adjunct to social determinants to identify high-risk patients for longitudinal outreach.

Accurate biomarkers are needed to characterize recurrence sites after optimal resection for metastatic colorectal cancer (mCRC). This study demonstrated that ctDNA detection timing and levels differ between peritoneal-only and distant recurrences. ctDNA testing offers the potential to guide treatments based on recurrent disease site involvement.

Surgical microwave ablation for colorectal liver metastasis is associated with minimal major morbidity and mortality and acceptable recurrence and survival patterns; a large, single institution review.

This study analyzed the impact of the COVID-19 pandemic on colorectal cancer operation, revealing a 17.3% reduction in cases. Patients undergoing operation in 2020 exhibited more advanced disease stages. Disparity was noted among vulnerable populations, emphasizing the enduring consequences of delayed cancer care during the pandemic.

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