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2015 Special Study Results Published

Clinical Research ProgramIn 2015, the Commission on Cancer partnered with the American College of Surgeons Clinical Research Program and investigators with funding through the Patient Centered Outcomes Research Institute (PCORI) to initiate a special study designed to improve the existing approach to surveillance after active treatment for lung, colorectal and breast cancers. With a long-term goal to develop a more patient-centered, individualized approach to post-treatment surveillance, the special study examined follow-up testing, recurrence, and survival to assess whether follow-up strategies could be tailored to individual risk.

Results from Principal Investigator Dr. Benjamin Kozower’s Post-Treatment Surveillance for Lung Cancer study, published in the Annals of Surgery, revealed that more frequent surveillance was not associated with improved overall survival, or post-recurrence survival, for patients with non-small cell lung cancer.

Principal Investigator Dr. George Chang’s study on Post-Treatment Surveillance for Colorectal Cancer, published in the Journal of the American Medical Association, demonstrated no significant association between frequency of surveillance testing and the time to detection of recurrence for colorectal cancer patients.

Principal Investigator Dr. Caprice Greenberg’s Post-Treatment Surveillance in Breast Cancer research studied breast cancer patients to determine frequency of post-treatment imaging. Study authors looked at the use of asymptomatic systemic imaging in an article entitled “A National Study of the Use of Asymptomatic Systemic Imaging for Surveillance Following Breast Cancer Treatment (AFT-01),” published in the Annals of Surgical Oncology. The Journal of Clinical Oncology published results in an article entitled “Risk of Synchronous Distant Recurrence at Time of Locoregional Recurrence in Patients With Stage II and III Breast Cancer (AFT-01) ,” which looked to determine appropriate treatment recommendations for systemic staging imaging at the time of locoregional breast cancer recurrence. Dr. Greenberg’s research also looked at utilization of mammography and breast MRI after breast cancer treatment, publishing the results in an Annals of Surgical Oncology article entitled “Use of Breast Imaging After Treatment for Locoregional Breast Cancer (AFT-01).”

The three study teams also collaborated to examine comorbidity assessment in the National Cancer Database, published in the Journal of Oncology Practice. Read more about those exciting results.

These research studies were supported, in part, through awards no. CE-1306-00727 (B.D.K.), CE-1304-6543 (C.C.G.), and CE-1304-6855 (G.J.C.) from the Patient-Centered Outcomes Research Institute.