American College Of Surgeons - Inspiring Quality: Highest Standards, Better Outcomes

Better ulcerative colitis outcomes with surgery

OCTOBER 26, 2017
Clinical Congress Daily Highlights, Thursday Edition

Ulcerative colitis patients who underwent surgical treatment reported better outcomes for disease-specific quality of life and general health than did patients treated with biological therapy, according to a study performed at Coimbra Medical School and University Hospital, Coimbra, Portugal. Both approaches are used to treat moderate to severe ulcerative colitis.

Julio F. Leite, MD, and colleagues invited patients to complete an inflammatory bowel disease questionnaire and the Short Form (SF-36) Health Survey.  The 46 patients in the surgery group had undergone restorative proctocolectomy with ileoanal pouch anastomosis and ileostomy closure from 2005 to 2015. The biological treatment group included 24 patients who were treated in the final three months of 2016 in an outpatient clinic.

Both groups had similar age and sex distribution. Pouch patients reported significantly better outcomes in the questionnaire than the biological group (178+30 vs. 153+41, p=0.01). The pouch group also had better general health scores than the anti-TNF group (76+17 vs 62+17, p=0.001), particularly in six of the eight SF-36 items: physical functioning, bodily pain, vitality, mental health, social impact, and general health.

The authors concluded that their results may provide a useful comparison of outcomes for physicians to consider when deciding on the treatment type.

Additional Information:
This Scientific Forum study was presented October 26 at the 2017 Clinical Congress of the American College of Surgeons in San Diego, CA. Program, webcast and audio information is available online at

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