Thyroid

--Holzer S, Reiners C, Mann K, Bamberg M, Rothmund M, Dudeck J, Stewart AK, Hundahl SA. Patterns of care for patients with primary differentiated carcinoma of the thyroid gland treated in Germany during 1996. Cancer 2000; 192-193. (!)

--Cady B. Comparative analysis of thyroid carcinoma in Germany and the U.S. Cancer 2000; 89:1-4. (!)

--Hundahl, SA, Cady B, Cunningham MP, Mazzaferri E, McKee RF, Rosai J, Shah JP, Fremgen AM, Stewart AK, Holzer S. Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996. Cancer 2000; 89:202-217. (!)

--Hundahl SA, Fleming ID, Fremgen AM, Menck HR. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995. Cancer 1999; 86:538-544. (!)

--Hundahl SA, Fleming I, Fremgen AM, Menck HR. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S. 1985-1995. Cancer 1998; 83:2638-2648. (!)

--Hundahl SA. Perspective: National Cancer Institute summary report about estimated exposures and thyroid doses received from Iodine131 in fallout after Nevada atmospheric nuclear bomb tests. CA 1998; 48:285-298.

--Hundahl SA, Fleming ID, Shah JP: Thyroid cancer. In: Steele GD, Jessup JM, Winchester DP, Menck HR, Murphy GP: eds. National Cancer Data Base: Annual review of patient care, 1995. Atlanta, GA: American Cancer Society; 1995, 100-112.

Data were received on 6,020 thyroid cancer cases from 1986-1987 and 6,423 cases from 1992. These data represent approximately 56% and 51% of all thyroid cancer diagnosed in the United States in 1986-1987 and 1991, respectively. The report identifies a curious relationship between incidence and relative survival rates for papillary, follicular, and medullary cancer. Each cancer afflicts females disproportionately, yet the prognosis for females appears to be better. Papillary and follicular cancer afflict younger age groups disproportionately, but these age groups also have a better prognosis. Disproportionately high numbers of papillary and follicular cancers were noted among Asian and Hispanic patients. The report also notes a weak and inconsistent relationship between tumor grade and relative survival rates, and an economically-based ratio of stage I to stage IV disease. AGES Score shows that while 81% of papillary thyroid carcinoma patients fell into the low-risk group, 54.3% of those patients underwent total thyroidectomy. Proponents of unilateral lobectomy with isthmusectomy suggest that at least 35% of patients with papillary carcinoma of the thyroid are surgically overtreated and unnecessarily placed at risk for complications caused by total thyroidectomy.

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