Hodgkin's Disease

--Kennedy BJ, Fremgen AM, Menck HR. Hodgkin's disease survival by stage and age. J Am Geriactr Soc 2000; 48:315-317. (!)

--Kennedy BJ, Fremgen AM, Menck HR. The National Cancer Data Base report on Hodgkin's disease for 1985-1989 and 1990-1994. Cancer 1998; 83:1041-1047. (!)

--Zaki A, Natarajan N, Mettlin CJ. Early and late survival in Hodgkin's disease among whites and blacks living in the United States. Cancer 1993; 72:602-606. (*)

--Kennedy BJ. Hodgkin's Disease. In: Steele GD, Winchester DP, Menck HR, Murphy GP: eds. National Cancer Data Base: Annual review of patient care, 1992. Atlanta, GA: American Cancer Society, 1992; 9-18.

Data from 637 hospitals provided 989 analytic cases in 1985, and 2,181 in 1988. The 1988 data in this report represent 29.5% of the estimated 7,400 cases diagnosed that year. Tables include percent of cases by age, sex, histologic type, clinical stage, and pathologic stage. Treatment is also presented by age, and best stage. Relative survival tables are presented by age, best stage, histology, stage group, and age group.

--Kennedy BJ, Loeb V, Peterson V, Donegan WL, Natarajan N, Mettlin CJ. Survival in Hodgkin's Disease by stage and age. Med Pediatr Onc 1992; 20:100-104. (*)

Patterns of care for Hodgkin's disease in the United States were surveyed through voluntary audits of hospitals both with cancer programs approved by the Commission on Cancer and programs that are not approved. Four hundred and seventy- three hospitals reported 6,345 patients diagnosed immediately preceding December 31, 1975. The survival rates varied with age; being better at younger ages and worse in the elderly. By pathologic stage, the younger patients faired better than the elderly in each stage grouping. Histologic type was not a factor in this poor prognosis. Hodgkin's disease in elderly patients has a different biologic behavior than in younger patients.

--Walker A, Schoenfeld ER, Lowman JT, Mettlin CJ, MacMillan J, Grufferman S. Survival of the older compared to younger patient with Hodgkin's Disease: The Influence of histology, staging, and treatment. Cancer 1990; 65:1635-1640. (*)

Age as an independent risk factor for survival of Hodgkin's disease (HD) was investigated using data for the 6,345 patients in the American College of Surgeons Patterns of Care Study. Patients were divided into two groups, 15 to 34 years of age and older than 50 years. Older patients had higher rates of advanced stage and B symptoms (i.e., stage IVB, 19.7% compared with 7.7%) and significantly higher rates of poor prognosis histologic types, odds ratio (OR)=3.7. The older population with clinical stage (CS) I and II disease was also less likely to have received any of the selected staging procedures, bone marrow biopsy, lymphogram, or laparotomy (OR=4.48). The two populations were equivalently understaged when CS was compared with pathologic stage (PS). In each category the older patients were more likely to have received no therapy; for PS I and II disease the OR for older patients compared with the younger patient was 2.14. When stratified by PS, B symptom status, histologic type, and treatment, the older patients continued to show poorer 5-year survival by the life-table method. The authors' hypothesis--that older patients equivalently staged and treated would have no significant difference in long-term survival--was not substantiated by the data. However, in the analyses in which corrections for the known risk factors were made, the difference in survival was not as great as that in the crude, unstratified data. This study, as well as other recent studies utilizing smaller numbers of patients, finds age an independent predictor of poorer survival in HD patients.

--Kennedy BJ. Leukemia and lymphoma in the elderly. In: Karger S, ed. Frontiers of radiation therapy and oncology cancer and the elderly. S. Karger Publishers, Inc. 1985. (*)

--Kennedy BJ, Loeb V, Peterson V, Donegan WL, Natarajan N, Mettlin CJ. National survey of patterns of care of Hodgkin's Disease. Cancer 1985; 56:2547-2556. (*)

Patterns of care for Hodgkin's disease were surveyed through voluntary audits of hospitals with cancer programs approved by the Cancer Commission of the American College of Surgeons. Four hundred seventy-three hospitals reported 6,314 patients in the long-term survey (patients diagnosed immediately preceding December 31, 1975), and 611 hospitals identified 3,168 new patients in the short-term study (patients diagnosed immediately following January 1, 1981). The latter represent 45% of the estimated annual incidence in the United States. Comparison of the two studies showed changes in the procedures employed in staging, including an increased use of lung and abdominal computed tomography and bilateral bone marrow biopsies. Use of upper mantle plus periaortic node radiotherapy increased, whereas the inverted-Y field decreased. The use of single-agent chemotherapy decreased, and MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) chemotherapy increased. The survival rates varied with age, being better at younger ages and worse in the elderly.

--Kennedy BJ, Loeb V, Peterson V, et al. National survey of patterns of care of Hodgkin's Disease. Med Pediatr Onc 1985; 13. (*)

--Kennedy BJ, Loeb V, Peterson V, et al. National survey of patterns of care of Hodgkin's Disease. Proc 20th Annual Meeting of the American Society of Clinical Oncology. May 6-8, 1984, Toronto, Canada. (*)

Clinical Infomation Bibliography